|
Intellectual Disability
|
0.400 |
Biomarker
|
group |
HPO |
|
|
|
|
Intellectual Disability
|
0.400 |
Biomarker
|
group |
CTD_human |
Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
|
21937992 |
2011 |
|
Multiple congenital anomalies
|
0.100 |
CausalMutation
|
group |
CLINVAR |
Enhanced utility of family-centered diagnostic exome sequencing with inheritance model-based analysis: results from 500 unselected families with undiagnosed genetic conditions.
|
25356970 |
2015 |
|
Foot Deformities
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Congenital contracture
|
0.100 |
Biomarker
|
group |
HPO |
|
|
|
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
VRK1 protein was detected in normal breast and in breast carcinomas at high levels in ER and PR positive tumors.
|
24731990 |
2014 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Vaccinia-related kinase 1 (VRK1) has been reported to participate in the development of a variety of tumors.
|
27319807 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Taken together, our findings suggest VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC.
|
26375549 |
2015 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Our analysis of human tumor tissue microarrays (TMAs) revealed that VRK1 protein levels are higher in lymph node metastases than in patient-matched mammary tumors.
|
30180179 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
The expression of CDCP1, IGF2R, IRAK3, LATS2, PIK3CB, ULK4, or VRK1 in primary GBM tumors was associated with recurrence-related prognosis.
|
26956052 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The accumulation of VRK1 in tumours with mutant p53 could result in stimulation of other signalling pathways that can contribute to tumour growth and progression in addition to those resulting from loss of p53 function.
|
17689819 |
2007 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Moreover, this effect of VRK1 is independent of TP53 or ATM, two genes frequently mutated in cancer.
|
31101118 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Vaccinia-related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over-expressed in dividing cells and regarded as a cancer drug target primarily due to its function as an early response gene in cell proliferation.
|
30461091 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Vaccinia-related kinase 1 (VRK1) has previously been identified as a cancer-related gene.
|
29029460 |
2017 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
VRK1-mediated MET might facilitate the colonization of distal sites by metastatic breast cancer cells, providing some insight into the frequent association of VRK1 overexpression with breast malignancies and the correlation between VRK1 overexpression and poor clinical outcome.
|
30180179 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Moreover, this effect of VRK1 is independent of TP53 or ATM, two genes frequently mutated in cancer.
|
31101118 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Vaccinia-related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over-expressed in dividing cells and regarded as a cancer drug target primarily due to its function as an early response gene in cell proliferation.
|
30461091 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
Vaccinia-related kinase 1 (VRK1) has previously been identified as a cancer-related gene.
|
29029460 |
2017 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
VRK1 protein level was significantly higher in squamous cell lung carcinomas than in adenocarcinomas, and inversely correlated with p16.
|
17689819 |
2007 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
These data indicate that the VRK1-p53 autoregulatory loop was not functional in a group of lung carcinomas.
|
17689819 |
2007 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, our study indicates that VRK1 and BANF are promising novel therapeutic targets for esophageal cancer.
|
28298069 |
2017 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Vaccinia-related kinases 1 and 2 (VRK1 and VRK2) are human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
|
31531195 |
2019 |
|
Olivopontocerebellar Atrophies
|
0.010 |
Biomarker
|
group |
BEFREE |
In contrast to the previous definition of PCH-1, our observations suggest the existence of milder phenotypes with pontocerebellar hypoplasia or olivopontocerebellar atrophy in combination with anterior horn cell loss.
|
12548734 |
2003 |
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings support VRK1 as a causative gene in adult-onset distal hereditary motor neuropathies, and its relevance for evaluation of patients with motor impairment among various populations.This article is protected by copyright.All rights reserved.
|
31837156 |
2020 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Mice engrafted with VRK1-depleted MDA-MB-231 breast cancer cells have been shown to develop fewer distal metastases than controls, suggesting VRK1 might play a role in cell migration, invasion, and/or colonization.
|
30180179 |
2018 |